Scientist, Preclinical Development (SC07-7)



TScan Therapeutics is a clinical-stage biotech seeking to revolutionize life-changing therapeutics for patients by identifying novel T cells and epitopes. We are looking for an experienced T cell immunologist to join our team as Scientist, supporting our IND-enabling studies to advance novel TCR-T cell therapy candidates to clinic. The ideal candidate should have relevant experience in primary T cell culture and engineering, immunoassays, flow cytometry, and tissue culture, and enjoy fast-paced, collaborative and vibrant startup culture. A team player with a sense of urgency will thrive in this role.


  • Engage in efforts to advance the preclinical development of our lead TCR-T cell assets and participate to IND-enabling studies
  • Use strong reasoning and analytical skills to design, execute, interpret and report results of functional assays with TCR-engineered T cell products (e.g., flow cytometry, cytotoxicity assay, cytokine secretion, T cell proliferation).
  • Collaborate with the in-vivo pharmacology team to develop relevant mouse models for characterizing in-vivo efficacy, T cell persistence and phenotypes.
  • Participate in writing IND study reports and IND-enabling documentation
  • Maintain detailed records of experiments, analyze and compile data, and present in group and company meetings.
  • Manage a junior direct report in the future


  • Ph.D. in immunology with 0-2 years of relevant post-doc/industry experience, with a strong background in T cell immunology is required.
  • Proficiency in developing and executing T cell functional assays such as immune cell isolation and engineering, proliferation, cytotoxicity, cytokine secretion and flow cytometry is required.
  • Experience performing IND-enabling studies or cell therapy is desired.
  • Strong publication record required and oral/poster presentation at conferences desired.
  • Independent thinker with excellent communication skills (both written and oral), ability to work in a matrix environment and experience presenting in team meetings.
  • Experience supervising and training students and research associates preferred.
  • Enthusiasm and willingness to learn new concepts, new techniques, participate in Journal club and work in a fast-paced environment.

About TScan:

TScan Therapeutics was founded in 2018 by a small group of scientists led by Dr. Stephen Elledge (Harvard Medical School/HHMI). TScan is discovering and developing novel TCR-engineered T cell therapies for the treatment of cancer. TScan’s discovery platform is centered around a breakthrough technology that enables the rapid, comprehensive, and genome-wide identification of the peptide antigen targets of T cell receptors. This technology greatly enhances our ability to understand the specific antigens that drive important disease processes, including tumor cell recognition by the immune system, self-reactivity in autoimmune disorders, and acquired immunity in infectious disease. TScan is using the platform in oncology to discover new TCR/target pairs and to rapidly move novel TCRs into clinical development.

Do YOU have the anatomy of a TScanner?

Our talented, compassionate and intelligent team is what makes TScan a great place to work. Our brand new offices with approximately 40,000 square feet of premium lab and office space is an environment that supports innovation, camaraderie and professionalism. We are driven, passionate, fun, flexible and team oriented. Sound like you? Apply today.

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