Scientist/Sr. Scientist, LNP (SC04-7)



TScan Therapeutics is a clinical-stage biotech seeking to revolutionize life-changing therapeutics for patients by identifying novel T cells and epitopes. We are looking for an experienced researcher to join our team as Scientist or Senior Scientist, supporting our novel gene delivery, target identification, and technology development workflows. The ideal candidate should have relevant experience in molecular biology, immune cell engineering using recent delivery mechanisms, and immunoassays, and enjoy a fast-paced, collaborative, and vibrant startup culture. A team player with a sense of urgency will thrive in this role.


  • Develop workflows designed to deliver nucleotide or protein cargo with lipid nanoparticles (LNPs)
  • Generate custom lipid formulations and targeting molecules to optimize LNP delivery of cargo to immune cells.
  • Conduct in vitro studies to assess the stability, encapsulation efficiency, and delivery kinetics of LNPs.
  • Assess the bioactivity and function of engineered T cells or other immune cells.
  • Survey the field for current technologies that can augment TScan workflows and evaluate them with in-house testing.
  • Perform and document experiments, analyze data, and present work regularly.


  • For Scientist: PhD in a scientific discipline and 2+ years of related experience, OR MS and 7+ years, OR BS and 10+ years
  • For Sr. Scientist: PhD in a scientific discipline and 5+ years of related experience, OR MS and 12+ years, OR BS and 15+ years
  • Experience delivering nucleotide or protein cargo by LNPs is required with a preference for developing custom lipid formulations for optimizing LNP delivery.
  • Molecular biology experience including nuclease editing or gene insertion is required.
  • Experience engineering T cells or other immune cells is preferred.
  • Experience with common immunoassays used in the immune-oncology space preferred.
  • Excellent written and communication skills with the ability to document experiments in a timely fashion and present scientific data.
  • Ability to work efficiently both independently and in a collaborative team environment.
  • Demonstrated quality, proficiency, and attention-to-detail.

About TScan:

TScan Therapeutics was founded in 2018 by a small group of scientists led by Dr. Stephen Elledge (Harvard Medical School/HHMI). TScan is discovering and developing novel TCR-engineered T cell therapies for the treatment of cancer. TScan’s discovery platform is centered around a breakthrough technology that enables the rapid, comprehensive, and genome-wide identification of the peptide antigen targets of T cell receptors. This technology greatly enhances our ability to understand the specific antigens that drive important disease processes, including tumor cell recognition by the immune system, self-reactivity in autoimmune disorders, and acquired immunity in infectious disease. TScan is using the platform in oncology to discover new TCR/target pairs and to rapidly move novel TCRs into clinical development.

Do YOU have the anatomy of a TScanner?

Our talented, compassionate and intelligent team is what makes TScan a great place to work. Our brand new offices with approximately 40,000 square feet of premium lab and office space is an environment that supports innovation, camaraderie and professionalism. We are driven, passionate, fun, flexible and team oriented. Sound like you? Apply today.