Careers

Senior/Principal Research Associate (RA05-1)

LOCATION: Waltham, MA

POSITION SUMMARY:

TScan Therapeutics is a startup biotech seeking to revolutionize life-changing therapeutics for patients by identifying novel T cells and epitopes. We are looking for an experienced researcher to join our team as Senior Research Associate/Principal Research Associate, supporting our novel TCR discovery and validation workflow in house. The ideal candidate should have relevant experience in T cell immunology, cancer cell culture and molecular biology, and enjoy fast-paced, collaborative and vibrant startup culture. A team player with a willingness to learn will thrive in this role.

ABOUT TSCAN:

T-Scan Therapeutics was founded in 2018 by a small group of scientists led by Dr. Stephen Elledge (Harvard Medical School/HHMI). TScan is discovering and developing novel TCR-engineered T cell therapies for the treatment of cancer. TScan’s discovery platform is centered around a breakthrough technology that enables the rapid, comprehensive, and genome-wide identification of the peptide antigen targets of T cell receptors. This technology greatly enhances our ability to understand the specific antigens that drive important disease processes, including tumor cell recognition by the immune system, self-reactivity in autoimmune disorders, and acquired immunity in infectious disease. TScan is using the platform in oncology to discover new TCR/target pairs and to rapidly move novel TCRs into clinical development.

RESPONSIBILITIES:

  • Evaluate and nominate candidate TCRs discovered from TScan’s TCR discovery screens for preclinical development.
  • Candidate to perform in vitro immune cell engineering to express candidate TCRs.
  • Perform immune cell assays such as tumor cell killing, cytokine production and T cell proliferation.
  • Engineer cancer cell lines with lentiviruses, culture and maintain cancer cell lines.
  • Isolate human PBMCs from leukopaks.
  • Candidate to maintain detailed records of experiments, analyze data and present in group and company meetings.

REQUIREMENTS:

  • B.S. with 3-10 years experience or M.S. with 1-8 years of experience in biopharmaceutical or biotechnology industry.
  • Proficiency in tissue culture, immune cell isolation and flow cytometry required. Experience with ELISA and cytotoxicity assays using IncuCyte desired.
  • Experience in T cell immunology desired; understanding of cancer biology and molecular biology a plus.
  • Excellent communication skills (both written and oral), ability to work in a matrix environment and experience presenting in team meetings.
  • Enthusiasm and willingness to learn new concepts, new techniques, participate in Journal club and work in a fast-paced environment.

Do YOU have the anatomy of a TScanner?

Our talented, compassionate and intelligent team is what makes TScan a great place to work. Our brand new offices with over 10,000 square feet of premium lab and office space is an environment that supports innovation, camaraderie and professionalism. We are driven, passionate, fun, flexible and team oriented. Sound like you? Apply today.

 

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Senior/Principal Research Associate (RA05-1)

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