Vice President, Clinical Development (VP30-3)



TScan Therapeutics is a clinical-stage biotech seeking to revolutionize life-changing therapeutics for patients by identifying novel T cells and epitopes. We are looking for a Vice President, Clinical Development to oversee the clinical development of our T-cell oncology therapies in solid tumors. The ideal candidate should have relevant experience leading an oncology clinical program from the IND stage through registrational studies and experience with cell therapy products.  The candidate should enjoy a fast-paced, collaborative, and vibrant startup culture. A hands on collaborative team player with a sense of urgency will thrive in this role.


  • Lead and execute the clinical development plan for solid tumor TCR-T cell therapy assets and potential combinations
  • Collaborate with internal and external stakeholders to design and execute a clinical development plan across multiple solid tumor indications that incorporates novel technologies, biomarker driven patient selection and implements efficient novel-novel combinations in the clinic
  • Author/lead key clinical trial documents such as IBs, protocols, ICFs, CRFs, etc. as well as clinical sections of regulatory filings such as pre-INDs and INDs.
  • Serve as the primary Medical Monitor for the solid tumor clinical trial program, including overseeing internal and external teams and providing medical guidance to CRO partners and clinical sites
  • Support safety and pharmacovigilance activities for solid tumors
  • Work closely with and provide input into clinical operations, regulatory, project management, manufacturing, business development and other internal functions to establish project timelines/risks and ensure execution and achievement of milestones
  • Collaborate with translational research to ensure key pharmacodynamic and biomarker endpoints are incorporated into the study design. Build the Solid Tumors Translational data analysis plan, including analysis of biopsy samples, peripheral blood, T cell engraftment, T cell activation and exhaustion markers, and cytokine profiles
  • Establish and maintain relationships with PIs, KOLs and other external stakeholders
  • Review, assess and interpret clinical trial data, present to key internal and external stakeholders including investors, KOLs, Board of Directors, etc
  • Lead clinical trial data publication efforts for solid tumors
  • Facilitate key meetings such as advisory boards, safety review committees, investigator meetings, etc


  • MD, MD/PHD
  • 5+ years of experience leading Clinical Development Phase 1 – 3 oncology clinical trials within pharma/biotech
  • Cell therapy and immunology experience are not required but desirable
  • Excellent oral and written business communication skills
  • Ability to work in a flexible, fast paced matrix environment
  • Ability to drive a team-oriented environment, motivate and influence others, lead strategic discussions and interact with critical internal and external stakeholders

About TScan:

TScan Therapeutics was founded in 2018 by a small group of scientists led by Dr. Stephen Elledge (Harvard Medical School/HHMI). TScan is discovering and developing novel TCR-engineered T cell therapies for the treatment of cancer. TScan’s discovery platform is centered around a breakthrough technology that enables the rapid, comprehensive, and genome-wide identification of the peptide antigen targets of T cell receptors. This technology greatly enhances our ability to understand the specific antigens that drive important disease processes, including tumor cell recognition by the immune system, self-reactivity in autoimmune disorders, and acquired immunity in infectious disease. TScan is using the platform in oncology to discover new TCR/target pairs and to rapidly move novel TCRs into clinical development.

Do YOU have the anatomy of a TScanner?

Our talented, compassionate and intelligent team is what makes TScan a great place to work. Our brand new offices with approximately 40,000 square feet of premium lab and office space is an environment that supports innovation, camaraderie and professionalism. We are driven, passionate, fun, flexible and team oriented. Sound like you? Apply today.

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