Dr. Aude Chapuis is an expert in adoptive T-cell immunotherapies and hematopoietic stem cell transplantation. She received her medical and research training in Switzerland and completed her postdoctoral training and oncology fellowship in Seattle, at the Fred Hutchinson Cancer Research Center and the University of Washington, where she is now a faculty member.
Dr. Chapuis and her team are expert at identifying and validating optimal high-affinity T cell receptors (TCRs), engineering T cells with specific TCR genes, preparing certified T cell products for clinical trials and assessing their function in patients. Ongoing studies aim to 1) improve the survival and intrinsic antitumor activity of transferred T cells and 2) modulate cells in tumor “microenvironments” to improve therapeutic T cell activity. She has prepared and maintained successful investigator-initiated Investigational New Drug applications for the U.S. F.D.A., and written and served as the Principal Investigator of numerous adoptive immunotherapy trials.