News

TScan Leveraging Its Platform to Understand T Cell Response to Coronavirus
Seeking Clinical/Translational Collaborators

March 19, 2020

Like many scientists, we are looking to use our expertise to help with the current coronavirus pandemic. We are using our platform to understand the T cell response to SARS-CoV-2 with the intention of making the resulting data publicly available. It is our hope that these data could better inform efforts to design a vaccine that confers long-term immunity.

We use a genome-wide scanning technology to rapidly identify the natural targets of T cell receptors (TCRs). TScan’s coronavirus library spans every peptide coding variant in all of the ~100 viral isolates of SARS-CoV-2 sequenced so far. Using our technology, we can rapidly determine the viral targets of ~1000 TCRs at a time. Our hope is that, by identifying the T cell targets in patients with varying severity of symptoms, as well as patients that have recovered from SARS-CoV-2 infection, we can identify protective epitopes that could better inform vaccine development.

We are seeking clinical/translational collaborators with access to single cell TCR sequencing data from COVID-19 patients (paired a/b sequences). We have the capability to rapidly synthesize the genes for thousands of TCRs and so only require the sequencing data to enable our research. Please contact us at info@TScan.com.