Position Summary:

TScan Therapeutics is a clinical-stage biotech seeking to revolutionize life-changing therapeutics for patients by identifying novel T cells and epitopes. We are looking for an experienced researcher to join our team as Principal Research Associate/Associate Scientist in the Molecular Assembly team, supporting our novel target identification and validation workflow in house. The ideal candidate should have relevant experience in cloning techniques and enjoy a fast-paced, collaborative, and vibrant culture. A team player with a sense of urgency will thrive in this role.

Responsibilities:

• Collaborate with other scientists to design and build various constructs and vectors in support of target/TCR discovery efforts.
• Assemble large libraries of peptides, TCRs, etc. using specialized cloning protocols.
• Perform medium- to high-throughput cloning experiments to support discovery efforts in target identification and validation.
• Analyze and interpret cloning and screening data (e.g., sequencing, functional assays) to guide construct design and optimization.
• Troubleshoot complex cloning and library construction challenges and propose scalable solutions.
• Lead group efforts towards technology development and improvement.
• Implement and optimize high-throughput workflows, including automation where applicable.
• Train co-workers on molecular cloning techniques.
• Maintain accurate and well-documented experimental records (e.g., ELN) to ensure data integrity and reproducibility.

Requirements:

• PhD with 0-2+ years of industry experience; Master’s degree with 5-7+ years of relevant lab experience, preferably in the biopharmaceutical or biotechnology industry.
• Hands-on experience in a variety of molecular cloning techniques, including Gibson Assembly, Golden Gate Assembly, Gateway recombination, etc.; experience constructing large-scale libraries is desirable.
• Highly organized with very strong attention to detail.
• Demonstrated ability to manage multiple projects and meet deadlines in a fast-paced environment.

• Ability to work both independently and collaboratively and adapt quickly to changing priorities.

• Scientific creativity, critical thinking, and problem-solving skills.
• Excellent written and verbal communication skills, with the ability to document experiments in an organized and timely fashion and to present scientific data to coworkers.
• Familiarity with sequence analysis tools, NGS, and basic bioinformatics workflows preferred.
• Knowledge of immunology concepts, especially TCR biology and antigen recognition, is preferred.

About TScan:

TScan Therapeutics is a fully integrated, next-generation TCR-T cell therapy company. Founded in 2018, TScan’s platform was developed by Stephen Elledge, Ph.D., and Tomasz Kula, Ph.D., at Brigham and Women’s Hospital and Harvard Medical School. TScan’s transformative platform enables rapid discovery of TCRs and targets for engineered T cell therapy. This technology is extremely versatile and is applicable across multiple therapeutic areas beyond cancers, including autoimmune disorders and infectious diseases.

Do YOU have the anatomy of a TScanner?

Our talented, compassionate, and intelligent team is what makes TScan a Top Place to Work (as ranked by The Boston Globe). Our state-of-the-art offices with over 70,000 square feet of premium lab space, including an internal GMP manufacturing suite, are an environment that supports innovation, camaraderie, and professionalism. We are passionate, fun, flexible, and team oriented. Sound like you? Apply today.

EEO Statement

TScan is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, citizenship status, sexual orientation, gender identity or expression, or any other characteristic identified by federal, state, or local laws where we operate. TScan provides reasonable accommodations to qualified applicants and employees with disabilities. To begin an interactive dialogue with TScan regarding a reasonable accommodation in connection with the hiring process and/or to perform the responsibilities of the position for which the applicant has applied, please contact the recruiter.

Pay Range: $95,000 – $122,500

Pay Transparency

TScan Therapeutics’ pay ranges are established based on external market data from third-party compensation surveys and our internal benchmarking. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Individual compensation within this range is commensurate with a candidate’s specific qualifications, including education, overall experience, relevant experience, and specific skills. We strive to ensure that compensation is competitive, equitable, and aligned with the value each TScanner brings to the role.

Recruitment & Staffing Agencies

TScan Therapeutics does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to TScan Therapeutics or its employees is strictly prohibited unless contacted directly by TScan Therapeutics’ internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of TScan Therapeutics, and TScan Therapeutics will not owe any referral or other fees with respect thereto.