Research Associate/Senior Research Associate, TCR Discovery (RA05-10)



TScan Therapeutics is a startup biotech seeking to revolutionize life-changing therapeutics for patients by identifying novel T cells and epitopes. We are looking for an experienced researcher to join our team as Research Associate or Senior Research Associate, supporting our novel TCR discovery workflow in house. The ideal candidate should have relevant experience in T cell immunology, cancer cell culture and flow cytometry, and enjoy fast-paced, collaborative, and vibrant startup culture. A team player with a willingness to learn will thrive in this role.


  • Engage and innovate on large-scale in vitro immune cell screening efforts to discover novel TCRs for therapeutic development.
  • Evaluate and nominate candidate TCRs for preclinical development.
  • Engineer T cells to express TCRs of interest using lentiviruses or transposons and perform TCR expression analysis by flow cytometry.
  • Engineer cancer cell lines to express or knock out target antigen. Routine cell line maintenance.
  • Engage in efforts to discover novel TCR antigens using the TScan platform.
  • Perform immune cell assays such as tumor cell killing, cytokine production and T cell proliferation.
  • Isolate primary immune cells from blood products such as leukopaks.
  • Analyze data, make figures for presentation, and present at group and company meetings.


  • B.S. with 0-5 or M.S. with 0-2 years of experience in biopharmaceutical or biotechnology industry experience.
  • Experience in T cell immunology, understanding of cancer biology and molecular biology a plus.
  • Proficiency in tissue culture, cell engineering, and flow cytometry is preferred, experience with ELISA and cytotoxicity assays using Incucyte desired.
  • Excellent communication skills (both written and oral), attention to detail, and ability to work in a matrix environment. Experience presenting in team meetings or conferences a plus.
  • Enthusiasm and willingness to learn new techniques, participate in team Journal Club and work in a fast-paced environment.

About TScan:

TScan Therapeutics was founded in 2018 by a small group of scientists led by Dr. Stephen Elledge (Harvard Medical School/HHMI). TScan is discovering and developing novel TCR-engineered T cell therapies for the treatment of cancer. TScan’s discovery platform is centered around a breakthrough technology that enables the rapid, comprehensive, and genome-wide identification of the peptide antigen targets of T cell receptors. This technology greatly enhances our ability to understand the specific antigens that drive important disease processes, including tumor cell recognition by the immune system, self-reactivity in autoimmune disorders, and acquired immunity in infectious disease. TScan is using the platform in oncology to discover new TCR/target pairs and to rapidly move novel TCRs into clinical development.

Do YOU have the anatomy of a TScanner?

Our talented, compassionate and intelligent team is what makes TScan a great place to work. Our brand new offices with approximately 40,000 square feet of premium lab and office space is an environment that supports innovation, camaraderie and professionalism. We are driven, passionate, fun, flexible and team oriented. Sound like you? Apply today.

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