Luoma et al. Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy. Cell (2022) Discovery of Tumor Antigens and TCRs for the Treatment of Solid Tumors.
Kula et al. T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. Cell (2019) Pioneering work on the TargetScan discovery platform.
Ferretti et al. Unbiased Screens Show CD8+ T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2 that Largely Reside outside the Spike Protein. Immunity (2020) TargetScan platform used to identify SARS-CoV-2 targets of T cells in recovering COVID-19 patients.
Al Malki et al. A Phase 1 Trial of TSC-100 and TSC-101, Engineered T Cell Therapies That Target Minor Histocompatibility Antigens to Eliminate Residual Disease After Hematopoietic Cell Transplantation. ASGCT 2023
Reshef et al. Trial in Progress: A Phase 1 Umbrella Study of TCR-Engineered T Cells That Target HA-1 (TSC-100) and HA-2 (TSC-101) to Treat Residual Leukemia after Hematopoietic Cell Transplantation. ASH 2022
Jurewicz et al. Discovery of PRAME-specific TCR-T cell therapy candidates for the treatment of solid tumors. SITC 2022
Boudot et al. Multiplexed TCR-T Cell Therapy Targeting MAGE-A1 and PRAME Enhances The Activity of Adoptive T Cell Therapy in Pre-Clinical Models. SITC 2022
Jangalwe et al. Discovery of TSC-200-A02: A Natural HPV16 E7-specific TCR-T Cell Therapy Candidate for the Treatment of HPV-positive Solid tumors. ASGCT 2022
Wang et al. Multiplexed TCR-T Therapy: A Strategy to Enhance the Efficacy of Engineered Adoptive Cell Therapy. ASGCT 2022
Chattopadhyay et al. Product Characteristics and Multi-Arm Clinical Trial Design for TSC-100 and TSC-101, TCR-T Cells That Target Leukemia Following Hematopoietic Cell Transplantation. ASH 2021
Nayar R. et al. Discovery of TSC-101: A First in Class Natural HA-2 Specific TCR to Treat Leukemia Following Hematopoietic Stem Cell Transplant Therapy. ASH 2021
Wang et al. Comprehensive Identification of Tumor-reactive TCRs and Cognate Targets for Novel TCR T-cell Cancer Therapies. ASGCT (2020)
Ferretti et al. Unbiased Genome-wide Discovery Using TScan Reveals Shared Immunodominant CD8+ T Cell Epitopes in SARS-CoV-2. ASGCT (2020)
Nayar et al. Discovery of TSC-100: A Natural HA-1-specific TCR to Treat Leukemia Following Hematopoietic Stem Cell Transplant Therapy. SITC (2020)
Corporate Presentation – June 2023
MacBeath, Discovery of immunodominant T cell targets in COVID-19 patients and design of novel T cell-based vaccines, Cell-Mediated Therapies for Infectious Disease Summit (2021)