Kula et al. T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. Cell (2019)
Pioneering work on the TargetScan discovery platform.
Ferretti et al. Unbiased Screens Show CD8+ T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2 that Largely Reside outside the Spike Protein. Immunity (2020)
TargetScan platform used to identify SARS-CoV-2 targets of T cells in recovering COVID-19 patients.
Nayar R. et al. Discovery of TSC-101: A First in Class Natural HA-2 Specific TCR to Treat Leukemia Following Hematopoietic Stem Cell Transplant Therapy. ASH 2021
Wang et al. Comprehensive Identification of Tumor-reactive TCRs and Cognate Targets for Novel TCR T-cell Cancer Therapies. ASGCT (2020)
Ferretti et al. Unbiased Genome-wide Discovery Using TScan Reveals Shared Immunodominant CD8+ T Cell Epitopes in SARS-CoV-2. ASGCT (2020)
Corporate Presentation – August 2021
MacBeath, Discovery of immunodominant T cell targets in COVID-19 patients and design of novel T cell-based vaccines, Cell-Mediated Therapies for Infectious Disease Summit (2021)