Technology

Publications

Papers

Luoma et al. Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy. Cell (2022) Discovery of Tumor Antigens and TCRs for the Treatment of Solid Tumors.

Kula et al. T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. Cell (2019) Pioneering work on the TargetScan discovery platform.

Ferretti et al. Unbiased Screens Show CD8+ T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2 that Largely Reside outside the Spike Protein. Immunity (2020) TargetScan platform used to identify SARS-CoV-2 targets of T cells in recovering COVID-19 patients.


Posters

Al Malki et al. Initial Results of a Phase 1 trial of TSC-100 and TSC-101, Engineered T Cell Therapies that Target Minor Histocompatibility Antigens to Prevent Relapse after Allogeneic Hematopoietic Cell Transplantation. ASH 2023

Ferretti et al. Discovery of novel MAGEC2 epitopes for TCR-T adoptive cell therapy from expanded T cell clones of TIL therapy products. SITC 2023

Tadros et al. Discovery of MAGE-A1-specific TCR-T cell therapy candidates to expand multiplex therapy of solid tumors. SITC 2023

Jangalwe et al. Non-clinical development of T-Plex component TSC-200-A0201: A natural HPV16 E7-specific TCR-T cell therapy for the treatment of HPV16-positive solid tumors. SITC 2023

Nayar et al. Overcoming tumor heterogeneity – Clinical trial assays to prospectively assign patients customized multiplexed TCR-T cell therapy in Phase 1. SITC 2023

Al Malki et al. Phase 1 trial of TSC-100 and TSC-101, Engineered T-Cell Therapies Targeting Minor Histocompatibility Antigens to Eliminate Residual Disease after Hematopoietic Cell Transplantation. SITC 2023

Chattopadhyay et al. Product Characteristics and Clinical Trial Design for T-Plex, a Multiplexed, Enhanced T cell Receptor-Engineered T cell Therapy for Solid Tumors. SITC 2023

Chattopadhyay et al. Product characteristics and clinical trial design for T-Plex: Multiplexed, enhanced T cell receptor-engineered T cell therapy for solid tumors. ASCO 2023

Al Malki et al. A Phase 1 Trial of TSC-100 and TSC-101, Engineered T Cell Therapies That Target Minor Histocompatibility Antigens to Eliminate Residual Disease After Hematopoietic Cell Transplantation. ASGCT 2023

Reshef et al. Trial in Progress: A Phase 1 Umbrella Study of TCR-Engineered T Cells That Target HA-1 (TSC-100) and HA-2 (TSC-101) to Treat Residual Leukemia after Hematopoietic Cell Transplantation. ASH 2022

Jurewicz et al. Discovery of PRAME-specific TCR-T cell therapy candidates for the treatment of solid tumors. SITC 2022

Boudot et al. Multiplexed TCR-T Cell Therapy Targeting MAGE-A1 and PRAME Enhances The Activity of Adoptive T Cell Therapy in Pre-Clinical Models. SITC 2022

Jangalwe et al. Discovery of TSC-200-A02: A Natural HPV16 E7-specific TCR-T Cell Therapy Candidate for the Treatment of HPV-positive Solid tumors. ASGCT 2022

Wang et al. Multiplexed TCR-T Therapy: A Strategy to Enhance the Efficacy of Engineered Adoptive Cell Therapy. ASGCT 2022

Chattopadhyay et al. Product Characteristics and Multi-Arm Clinical Trial Design for TSC-100 and TSC-101, TCR-T Cells That Target Leukemia Following Hematopoietic Cell Transplantation. ASH 2021

Nayar R. et al. Discovery of TSC-101: A First in Class Natural HA-2 Specific TCR to Treat Leukemia Following Hematopoietic Stem Cell Transplant Therapy. ASH 2021

Wang et al. Comprehensive Identification of Tumor-reactive TCRs and Cognate Targets for Novel TCR T-cell Cancer Therapies. ASGCT (2020)

Ferretti et al. Unbiased Genome-wide Discovery Using TScan Reveals Shared Immunodominant CD8+ T Cell Epitopes in SARS-CoV-2. ASGCT (2020)

Nayar et al. Discovery of TSC-100: A Natural HA-1-specific TCR to Treat Leukemia Following Hematopoietic Stem Cell Transplant Therapy. SITC (2020)


Presentations

Company Presentation – February 2024

MacBeath, Discovery of immunodominant T cell targets in COVID-19 patients and design of novel T cell-based vaccines, Cell-Mediated Therapies for Infectious Disease Summit (2021)