POSITION SUMMARY:

TScan Therapeutics is a clinical-stage biotech seeking to revolutionize life-changing therapeutics for patients by identifying novel T cells and epitopes. We are looking for an enthusiastic researcher to join our team as a Research Associate/Senior Research Associate in the Viral Vector & Discovery Platform team, supporting our novel target identification and validation workflow in-house. The ideal candidate should have relevant experience in mammalian tissue culture, lentivirus and retrovirus-based cell transduction and engineering, qPCR and basic flow cytometry, and enjoy a fast-paced, collaborative, and vibrant startup culture. A team player with a sense of urgency will thrive in this role.

RESPONSIBILITIES:

• Execute small and large scale high-titer lentivirus packaging and purification tasks to support the company’s high-throughput discovery projects and target/TCR validation.
• Execute RNA and protein-based QC experiments to monitor and ensure the quality of lentivirus generated in-house.
• Organize and keep track of DNA vector usage for research use.

REQUIREMENTS:

• RA: Bachelor’s degree with 0-3+ years of relevant laboratory experience, preferably in the biopharmaceutical or biotechnology industry. SRA: Bachelor’s degree with 3-5+ years of relevant laboratory experience or Master’s degree with 0-2+ years of relevant lab experience, preferably in the biopharmaceutical or biotechnology industry.
• Experience with mammalian tissue culture.
• Experience with lentivirus- and retrovirus-based cell transduction and engineering.
• Familiarity with qPCR and basic flow cytometry.
• Hands-on experience with basic molecular biology, cloning, Western blot, ELISA, luciferase assays is preferred.
• Excellent written and verbal communication skills, with the ability to document experiments in an organized and timely fashion and to present scientific data to coworkers.
• Ability to work efficiently both independently and in a collaborative team environment and to quickly pivot and adapt with any changing priorities.
• Strong attention to detail, analytical and trouble-shooting skills.
• Additional preferred skills include experience with CRISPR-based gene editing techniques, and primary T cell culture and editing.

About TScan:

TScan Therapeutics was founded in 2018 by a small group of scientists led by Dr. Stephen Elledge (Harvard Medical School/HHMI). TScan is discovering and developing novel TCR-engineered T cell therapies for the treatment of cancer. TScan’s discovery platform is centered around a breakthrough technology that enables the rapid, comprehensive, and genome-wide identification of the peptide antigen targets of T cell receptors. This technology greatly enhances our ability to understand the specific antigens that drive important disease processes, including tumor cell recognition by the immune system, self-reactivity in autoimmune disorders, and acquired immunity in infectious disease. TScan is using the platform in oncology to discover new TCR/target pairs and to rapidly move novel TCRs into clinical development.

Do YOU have the anatomy of a TScanner?

Our talented, compassionate and intelligent team is what makes TScan a great place to work. Our brand new offices with approximately 40,000 square feet of premium lab and office space is an environment that supports innovation, camaraderie and professionalism. We are driven, passionate, fun, flexible and team oriented. Sound like you? Apply today.